In a meta-analysis of seven trials studying probiotic supplementation in women with PCOS, there was a significant reduction in triglyceride levels, fasting insulin, and HDL without a significant impact on HOMA-IR, fasting blood glucose, LDL, total cholesterol, CRP, and anthropometric indices (i.e., weight, BMI, and waist circumference) [66]. The gene discussed is CRP; the disease is polycystic ovary syndrome.