APOE and metabolic syndrome: These phenotypes are associated with pathogenic variants in genes such as ABCA1, ABCG5, ALMS1, APOA1, APOA5, APOC2, APOC3, APOE, CREB3L3, GPIHBP1, LDLRAP1, LIPA, LMF1, and LPL, and are classified among the rare dyslipidemias frequently encountered in the monogenic dyslipidemia literature (e.g., EAS consensus) [8,9].