Literature reviews indicate bidirectional interactions between the endocrine system and peri-implant tissue healing: GH and IGF-1 may promote early bone-to-implant contact (BIC) and bone remodeling in the initial healing phase, although this effect is strongly dependent on endocrine balance and local inflammatory status, factors that are often disrupted in active acromegaly [17]. This evidence concerns the gene IGF1 and acromegaly.