TARDBP and amyotrophic lateral sclerosis: Building on the extraordinary outcomes and recognizing the need for a safe, effective, and noninfectious alternative, Abreu developed a computerized, digitally controlled, intelligent, hypothalamus-guided platform designed to replicate the high fever cyclical patterns of malarial infection [49,50,51,52] to induce heat shock response, which is known to facilitate clearance of misfolded TDP-43 in experimental model of ALS [27,28].