The upregulation of endogenous HSPs during CBIT2 thus offers a promising avenue for ALS treatment and disease reversal, paralleling the outcomes of malarial fever therapy that achieved clinical cure in neurosyphilis despite structurally damaged brain tissue harboring misfolded TDP-43, which is also present in ALS, further supporting the plausibility of a cure for ALS. Here, TARDBP is linked to neurosyphilis.