We have added a focused subsection in the Discussion detailing how the miR-192 → ITGB1 and miR-30d → TIMP3 axes plausibly regulate extracellular-matrix (ECM) remodeling, adhesion/FAK–MAPK signaling, and protease control-pathways that were enriched in our Enrichr analysis (e.g., proteoglycans in cancer, cell cycle, MAPK signaling) and involve our three prognostic genes (ITGB1, TIMP3, BRAF) highlighted in the pathway heatmap. The gene discussed is ITGB1; the disease is cancer.