PTK2 and cancer: We have added a focused subsection in the Discussion detailing how the miR-192 → ITGB1 and miR-30d → TIMP3 axes plausibly regulate extracellular-matrix (ECM) remodeling, adhesion/FAK–MAPK signaling, and protease control-pathways that were enriched in our Enrichr analysis (e.g., proteoglycans in cancer, cell cycle, MAPK signaling) and involve our three prognostic genes (ITGB1, TIMP3, BRAF) highlighted in the pathway heatmap.