Alongside clinical assessment and medical history, adjunctive laboratory investigations, such as inflammatory markers, tuberculosis screening, Crohn’s-related serologies, serum angiotensin-converting enzyme (ACE) and chitotriosidase (CTO) levels together with chest imaging for sarcoidosis, are often necessary to establish the correct diagnosis and rule out systemic disease [11,43,48]. This evidence concerns the gene ACE and sarcoidosis.