KRT88P and hepatitis B virus infection: The EASL (European Association for the Study of the Liver) 2025 Hepatitis B guideline defines HBVr as a sudden escalation in HBV replication occurring in HBsAg-positive individuals with an inactive profile (HBeAg-negative chronic infection), or in HBsAg-negative individuals with resolved hepatitis B (HBsAg-negative, anti-HBc-positive).