AGER and cardiac hypertrophy: Post-hoc tests confirmed a significant VW increase in WT mice (p < 0.05), but not in RAGE KO (p = 0.1831) or RapKO (p = 0.9999) mice, indicating that AngII induced cardiac hypertrophy in WT mice while RAGE KO and RapKO mice were resistant (Figure 1B).