Studies have shown that these senescence markers are elevated in rodent models of hypertension induced by DOCA-salt (Deoxycorticosterone Acetate-salt), diabetic nephropathy (DN) caused by streptozotocin (STZ), and cisplatin-induced nephrotoxicity [117,118,119]; particularly in DN, senescence markers like SA-β-Gal and p16 are associated with clinical parameters such as BMI, LDL cholesterol, and blood glucose levels. Here, CDKN2A is linked to liver dysplastic nodule.