In GSE126078 [24], which included PDXs derived from the same parental tumor (LuCaP 173), the small-cell neuroendocrine PCa (SCNPC) line (LuCaP 173.1) exhibited higher FGF12 expression than the double-negative PCa (DNPC) line (LuCaP 173.2), supporting its upregulation in t-NEPC in vivo. Here, FGF12 is linked to posterior cortical atrophy.