Eosinophil-deficient mice exhibited increased CD8+ T cell apoptosis, accompanied by a weakened acute immune response and impaired development of antigen-specific memory CD8+ T cells at later time points, with the most profound defects observed in central and peripheral effector memory cells (CD8+ TCEM and TPEM, respectively), accompanied by impaired recall responses to secondary infection [98]. The gene discussed is CD8A; the disease is infection.