CD4 and neoplasm: In mice and humans, phenotypes of lung metastatic and colorectal tumor-associated eosinophils exhibited IFNγ and TNFα response signatures, primarily shaped by the tumor microenvironment (TME), and their presence was associated with enhanced recruitment of CD4+ and/or CD8+ T cells [104,105], presumably in part due to IFNγ-elicited secretion of T cell chemoattractants.