In multiple cancers (e.g., triple negative breast cancer (TNBC) and non-small cell lung carcinoma (NSCLC), ICB was associated with the expansion of IL-5-secreting CD4+ T cells, contributing to eosinophil expansion and recruitment into the TME, which corresponded to increased expression of activated CD8+ T cell signatures in immunotherapy responders [108]. This evidence concerns the gene CD4 and non-small cell lung carcinoma.