Akt, also known as protein kinase B (PKB), which is one of the key proteins downstream of PI3K, is phosphorylated by PI3K and can enter into the nucleus and the cytoplasm, resulting in the phosphorylation of a series of substrates, which play a role in the cell’s regulation of cell death and proliferation and chemotherapy tolerance, thereby affecting the proliferation, survival, cycle, and growth of tumor cells [32]. Here, AKT1 is linked to neoplasm.