Accordingly, in the cortical bone of 3xTg-AD mice we also found a significant increment in the Total Area of OC activity compared with wild-type littermates (+2.3-fold, p = 0.0187) (Figure 5D), the evidence was not traceable in the trabecular bone of both mice groups (p = 0.9386) (Figure 5E). Here, BGLAP is linked to Alzheimer disease.