Moreover, TRAP staining indicated a 29% decrease in the Number of TRAP+ OYs in 3xTg-AD mice compared to littermate control mice (p = 0.0361) (Figure 4D), implying that in the cortical bone of AD mice, there is an impaired osteocytic osteolysis, a process through which OYs remove and remodel their perilacunar matrix [40]. Here, ACP5 is linked to Alzheimer disease.