Jagged1 is frequently overexpressed across multiple tumor types, and its transcription is regulated by several oncogenic signaling pathways, including Wnt/β-catenin [148], IL-6/STAT3 [149], TGF-β [150], NF-KB [151], SOX12 promoting stem cell-like phenotypes [152], and even Notch signalling itself [20,108]. This evidence concerns the gene JAG1 and neoplasm.