NOTCH1 and neoplasm: It is known that the Notch pathway is involved in epithelial–mesenchymal transition (EMT) events [7,9], in modulating the tumor microenvironment (TME) [10], and in regulating cancer stem cells (CSCs) self-renewal and survival [11,12] through preferential interactions between the ligand–receptor pair Jagged1 and Notch1.