This complex activates genes such as PTCRA and JAG1, further reinforcing the loop in an autocrine fashion in immature T cell lines and sustains survival, proliferation, and invasion, contributing to the development and progression of Notch-dependent T-ALL [20], suggesting an oncogenic role for Jag1-ICD in a Notch-dependent manner (Figure 2, left panel). The gene discussed is JAG1; the disease is acute lymphoblastic leukemia.