β-Catenin bound to the KDM4C promoter, and the binding of β-catenin and KDM4C onto the JAG1 promoter is essential during colon sphere formation, suggesting that KDM4C maintains the sphere-forming capacity in CRC by mediating the β-catenin-dependent transcription of JAG1 in a feed-forward manner [201]. This evidence concerns the gene JAG1 and colorectal carcinoma.