Calpain-1 (Capn1) and calpain-2 (Capn2) are expressed in different epithelial cells, such as respiratory, gastrointestinal, urinary tract, and reproductive tract cells, including the breast tissue environment, and human lens epithelial cells (LECs), where they play a critical role in epithelial cell immune-modulatory functions and death under different inflammatory insults, including infectious diseases, ischemia, and cataract (Figure 1) [15,42,43,44]. This evidence concerns the gene CAPN2 and infectious disease.