Endothelial calpastatin, by inhibiting calpains, prevents degradation of the suppressor of cytokine signaling 3 (SOCS3) molecule, keeping in check the IL-6/STAT3/VEGF-C axis-mediated neoangiogenesis in inflammatory hypoxic environments seen in the tumor microenvironment (TME), diabetic retinopathy, and non-healing wounds [114,115,116]. Here, SOCS3 is linked to neoplasm.