The immunosuppressive plasmacytoid DCs (pDCs) in human lung cancer TME secrete mature IL-1α due to the activation of absent in melanoma-2 (AIM-2)-like receptor (ALR)-based inflammasomes, which increase intracellular Ca2+, activating cytosolic calpains to generate mature IL-1α [236]. The gene discussed is IL1A; the disease is melanoma.