ROCK2 and neoplasm: Furthermore, the proteomic analysis revealed the significant upregulation of Ras homolog family member A (RhoA) and Rho-associated coiled-coil containing kinases 1 and 2 (ROCK1 and ROCK2) in PAK4KO cancer cells (Figure 7c), providing additional molecular evidence supporting the enhanced VM observed in PAK4KO tumours.