AKT1 and cancer: Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9125 tumors cross 33 cancer types, a comprehensive study analyzed ten oncogenic signaling pathways including PI-3-Kinase/Akt, Hippo, Myc, RTK-RAS, Notch, Nrf2, TGFβ signaling, p53, β-catenin/Wnt and cell cycle.