TP53 and neoplasm: Single-cell multiomics identified chronic inflammation as a driver of TP53-mutant leukemic evolution [19], revealed that FABP1 + renal cell carcinoma drive tumor angiogenesis through the PLG-PLAT axis under fatty acid reprogramming [20], revealed context-dependent roles for susceptibility genes by mapping transcriptomes and chromatin accessibility of 117,911 human lung cells from ever- and never-smokers [21], identified key mediators of lasting CAR T therapy response from 695,819 pre-infusion CAR T cells [22].