Our lab has also shown that downregulation of IgE may be linked to inhibition of XBP1, BLIMP1, STAT6 and mitochondrial metabolic activity, together with enhanced B cell lymphoma 6 (BCL-6), leading to restricted energetic support and transcriptional activation for IgE heavy chain and light chain synthesis and antibody glycosylation in U266 IgE myeloma cells [4]. The gene discussed is IGHE; the disease is plasma cell myeloma.