Prior human studies have implicated plasma hsa-let-7a-5p in regulating innate immune genes such as TLR3, RIG-I, and MDA5 in AD patients with allergic conjunctival disease (ACD) [56], and in autoimmune disease (vitiligo) through modulation of autophagy and apoptosis [57]. The gene discussed is TLR3; the disease is granular corneal dystrophy type II.