Women with PCOS demonstrate increased C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-18 (IL-18), tumor necrosis factor-α (TNF-α) and white blood cell counts together with dysregulation of pro- and anti-inflammatory mediators in serum and follicular fluid [31,32,33,34,35,36,37]. The gene discussed is TNF; the disease is polycystic ovary syndrome.