Similarly, base editing of regulatory SNPs within PCOS-associated enhancers (e.g., near FSHR, GATA4 or LHCGR) in granulosa-like induced pluripotent stem cell (iPSC)-derived cells can provide direct evidence of variant-driven transcriptional modulation [193,194,195]. Here, LHCGR is linked to polycystic ovary syndrome.