Moreover, PI3K/Akt/mTor signaling is downstream of RTKs, such as the PDGFR and EGFR pathways, indicating that the dysregulation of autophagy, a conserved cellular process involved in the degradation and recycling of cellular components, plays an important role in GBM pathogenesis and response to therapy [15]. The gene discussed is AKT1; the disease is glioblastoma.