In addition, GBM often exhibits an increased expression of other autophagy-associated proteins with the amplification of ULK1/ULK2 [37] and lysosomal markers such as Cathepsin D and LAMP2A; in addition, the lysosomal biogenesis transcription factor TFEB was found to be increased in GBM [37] (Figure 5). Here, CTSD is linked to glioblastoma.