Notably, DNA (cytosine-5)-methyltransferase 3A (DNMT3A), which functions in de novo methylation, and TET methylcytosine dioxygenase 2 (TET2), which initiates demethylation, are frequently mutated in clonal hematopoiesis of indeterminate potential, known as an indicator for aging-related diseases like coronary heart disease and hematological cancers [263,264,265]. The gene discussed is DNMT3A; the disease is hematopoietic and lymphoid cell neoplasm.