In cervical cancer, serum proteins CEA, squamous cell carcinoma antigen (SCCA), high mobility group box chromosomal protein 1 (HMGB1), and CYFRA 21-1 were analyzed in 36 cervical cancer patients to identify reliable biomarkers associated with human papillomavirus (HPV) infection [385]. The gene discussed is HMGB1; the disease is cervical carcinoma.