Beyond MPNSTs, individuals with NF1 carry a higher-than-average risk for various other cancers, including leukemia, breast cancer, gastrointestinal stromal tumors (GISTs), and pheochromocytomas, resulting in a reduced life expectancy—by an estimated 10 to 20 years compared to the general population—making NF1 a complex and lifelong clinical challenge [15,16]. This evidence concerns the gene NF1 and gastrointestinal stromal tumor.