Progression from pNFs to ANNUBPs and ultimately to MPNSTs involves the accumulation of additional genetic alterations (both mutations and copy number changes) including the cell cycle regulator CDKN2A/B, the tumor suppressor TP53 and components of the PRC2 complex, such as EED and SUZ12, which drive tumor aggressiveness and malignancy [9,10,11,12,13]. Here, TP53 is linked to neoplasm.