KRAS and lung carcinoma: Baldelli et al. studied the influence of a co-existing WT KRAS allele alongside the mutant KRAS on signaling networks in lung cancer cells using a reverse-phase protein array (RPRA) and demonstrated that retaining the WT KRAS allele within tumors harboring mutant KRAS can lead to significantly different signaling as compared to in cells that have only the mutant KRAS allele [26].