The core breast needle biopsy and the cytological evaluation of the axillary lymph node revealed an infiltrative, non-special-type, grade 3, HER2-positive (immunohistochemical score 3+), hormone receptors (HR) negative breast carcinoma, associated with numerous atypical and frank neoplastic cells in the ipsilateral axillary lymph node. Here, ERBB2 is linked to breast carcinoma.