In AD, certain miRNA molecules exhibit potentially immunosuppressive activity, such as miRNA-124, miRNA-1294, miRNA-205 and miRNA-146a via regulating crucial parts of the NF-κB pathway in keratinocytes and different immune cells, or miRNA-143 via targeting IL-13Rα1 in keratinocytes silencing IL-13-mediated decreased expression of filaggrin, involucrin and loricrin [21,27,28,29,37,39,40,43,46,47]. Here, FLG is linked to Alzheimer disease.