HIPK3 and atopic conjunctivitis: Lastly, in animal models of allergic conjunctivitis, the pollen-induced downregulation of miRNA-146a was followed by the enhanced expression of TSLP/TSLPR/OX40L/CD11C molecules, while the other investigation revealed that the overexpression of miRNA-146a induced the upregulation of FOXP3, one of the essential transcription factors in promoting Treg cells, the further suppression of inflammation through targeting HIPK3 (homeodomain-interacting protein kinase 3) and reduced phosphorylation of STAT3 [93,94].