Assessing the clinical potential of miRNA-203 in pediatric AD, scientists found that miRNA-203 serum levels were significantly elevated and in a positive correlation with the increase in serum TNFRI and TNFRII, whilst they detected the decreased miRNA-203 expression in urine and the inverse relation to serum IgE levels, suggesting miRNA-203 as an appropriate disease biomarker [17,43,47,60]. This evidence concerns the gene IGHE and Alzheimer disease.