TNF and systemic lupus erythematosus: It was found that miRNA-146a controls the suppression of TNF-mediated osteoclastogenesis in rheumatoid arthritis (RA), while the decreased expression of miRNA-146a due to the rs2431697 variant in the miRNA-146a gene in systemic lupus erythematosus (SLE) can lead to altered IFN signaling and progression of the disease [75].