The main findings of the present study are: (1) T2DM patients with higher PISA scores tend to be at greater risk for MCI, and (2) moderate significant correlations were observed between inflammation and MCI risk blood-based biomarkers, specifically between PISA and ApoC1, IL-6 and ApoA1, and CRP with ApoA1, C3, and Hemopexin. The gene discussed is C3; the disease is type 2 diabetes mellitus.