CD40LG and alcoholic hepatitis: P. gingivalis may also be relevant in alcohol-related liver disease: Zhou et al., 2018 [39], found higher plasma antibodies (IgG/IgA/IgM) to P. gingivalis in acute alcoholic hepatitis (AAH)—especially severe AAH—with IgM responses correlating with indices of liver injury; long-standing alcohol exposure appeared to attenuate IgM responsiveness.