In unstratified analyses, LMEMs revealed a significant increase in phagocytic CD14 +CD16 cells (classical monocytes) and a decrease in CD14+ cells (total monocytes), CD14+ CD16+ cells (intermediate monocytes), CD8+ PD-1+ T cells, and CD8+ CD40+ T cells in those on AD but not on WD (Fig. 3). The gene discussed is CD40; the disease is Wilson disease.