303 Di Sessa Di Sessa A A Grandone Grandone A A Marzuillo Marzuillo P P Umano Umano GR GR Cirillo Cirillo G G Del Giudice Del Giudice EM EM Early Menarche is Associated with Insulin-Resistance and Non-Alcoholic Fatty Liver Disease in Adolescents with Obesity Early Menarche is Associated with Insulin-Resistance and Non-Alcoholic Fatty Liver Disease in Adolescents with Obesity J Pediatr Endocrinol Metab J Pediatr Endocrinol Metab 2021 2021 34 34 5 5 607 607 612 612 10.1515/jpem-2020-0684 10.1515/jpem-2020-0684 33823088 33823088. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.