370 Drucker Drucker DJ DJ GLP-1-Based Therapies for Diabetes, Obesity and Beyond GLP-1-Based Therapies for Diabetes, Obesity and Beyond Nat Rev Drug Discov Nat Rev Drug Discov 2025 2025 10.1038/s41573-025-01183-8 10.1038/s41573-025-01183-8. Here, GCG is linked to obesity due to melanocortin 4 receptor deficiency.