For instance, researchers observed elevated long noncoding RNA H19 expression in thoracic aorta tissues of AD patients and PDGF‐BB‐stimulated human aortic smooth muscle cells (HASMCs), which correlated with increased MMP‐2/9 levels, decreased contractile markers (α‐SMA/SM22α), and enhanced cell proliferation/migration [10]. The gene discussed is MMP2; the disease is Alzheimer disease.