Pathogenic variants in SPG11, which encodes spatacsin, are causative for spastic paraplegia type 11 (SPG11-HSP).44 SPG11-HSP represents the most frequent form of complex autosomal recessive HSP, whose clinical phenotype of SPG11-HSP is characterised by progressive neurodegeneration. The gene discussed is SPG11; the disease is hereditary spastic paraplegia.