An interesting finding was noted for the genetic mimicry of ANGPTL3 inhibition on the harmful effect of osteonecrosis risk in the MR analysis (OR = 2.99 [95% CI 1.39–6.44], p = 5.2 × 10−3) and this observation was validated in GRS analysis (OR = 1.004 [95% CI 1.001–1.007], p = 0.004). Here, ANGPTL3 is linked to osteonecrosis.