HMGCR expression in blood tissue and osteonecrosis shared a causal variant (rs6453133) (blood tissue: PP.H4 = 0.999) (Table S20 and Figure S5), whereas the colocalisation finding of ANGPTL3 expression was poorly identified (liver tissue: PP.H4 = 0.012) (Table S21 and Figure S6). The gene discussed is HMGCR; the disease is osteonecrosis.