Additionally, p97 co-localizes with protein aggregates involved in several neurodegenerative diseases, suggesting that its segregase and unfoldase activities could be related to the proteolytic control of proteins of therapeutic interest (Galindo-Moreno et al., 2017; Hirabayashi et al., 2001; Mizuno et al., 2003; Yang and Hu, 2016; Kobayashi et al., 2007; Alieva et al., 2020). Here, VCP is linked to neurodegenerative disease.