Our results are in line with recent, large‐scale, randomized clinical trials reporting no differences in the incidence of postoperative delirium between general and regional anesthesia.[44, 70] Notably, previous studies that have reported anesthesia‐induced cognitive deficits in aged rodents often employed longer or repeated anesthetic exposures.[71] Further investigation using varied anesthesia protocols will be essential to determine whether failure to activate ATF5‐dependent UPRmt contributes to cognitive dysfunction in the aging brain. The gene discussed is ATF5; the disease is Cognitive impairment.