The results showed that HDL (P<.001, OR = 0.176, 95% CI:0.144~0.215), smoking (P = .002, OR = 0.759, 95% CI:0.620~0.92), LDL (P = .021, OR = 0.811, 95% CI:0.678~0.969), BMI (P = .001, OR = 0.815, 95% CI:0.726~0.915), TyG (P = .038, OR = 1.091, 95% CI:1.005, 1.185), age (P = .014, OR = 1.149, 95% CI:1.028~1.284), hypertension history (P<.001, OR = 1.506, 95% CI:1.273~1.781), course of T2DM (P<.001, OR = 1.798, 95% CI:1.615~2.002), insulin therapy (P<.001, OR = 3.166, 95% CI:2.621~3.824), HbA1c (P<.001, OR = 3.443, 95% CI:2.879~4.116), were the independent influencing factors of DR (Table 2). This evidence concerns the gene INS and Hypertension.