Gómez de Segura et al. (33) demonstrated through integrated clinical and in vitro analyses that decreased expression of microfibril-associated glycoprotein-1 (MAGP-1, encoded by MFAP2 gene) in obesity-associated colon cancer leads to dysregulated TGF-β1 signaling and subsequent upregulation of SPP1. Here, MFAP2 is linked to obesity due to melanocortin 4 receptor deficiency.