Brain-derived neurotrophic factor (BDNF) has also been suggested to play an important role in the pathogenesis of FD, and Ly et al. (78) found that the level of BDNF was significantly reduced in patients with FD, which may lead to abnormalities in the regulation of gastrointestinal tract function by the central nervous system. The gene discussed is BDNF; the disease is Fabry disease.