AC = anti-coagulation; ATT = antithrombotic therapy; ASA = acetylsalicylic acid; AE = adverse events; BNF = British National Formulary; COU = coumadin; CRIF = closed reduction internal fixation; DOAC = direct oral anticoagulant; DVT = deep vein thrombosis; Hb = haemoglobin; PAI = platelet aggregation inhibitors; PCC = prothrombin complex concentrate; PE = pulmonary embolism; VKA = vitamin K antagonist; THA = total hip arthroplasty; LMWH = low-molecular-weight heparin; VTE = venous thromboembolism; LOS = length of stay: TTS = time to surgery. The gene discussed is F2; the disease is deep vein thrombosis.