SERPINC1 and Sepsis: In view of these aspects, we cannot rule out the possibility that the consumption of antithrombin III, which is caused by binding with sSDC1 [28] or by excessive thrombin activation in patients with sepsis, may more prominently manifest the effect of the thrombin added as an anticoagulant in the blood-collection tube and consequently, enhance the generation of the 75 kDa derivative.