In addition, IL-1R2 expression is minimal in cluster 9 (Figures 2A,B,E,F), which co-expressed Adgre1, Clec4f and Tim4 and identified as resident macrophages, namely Kupffer cells in the liver (Supplementary Figures S2E,G,H), and this expression did not increase in response to sepsis. Here, TIMD4 is linked to Sepsis.