CLEC4F and Sepsis: In addition, IL-1R2 expression is minimal in cluster 9 (Figures 2A,B,E,F), which co-expressed Adgre1, Clec4f and Tim4 and identified as resident macrophages, namely Kupffer cells in the liver (Supplementary Figures S2E,G,H), and this expression did not increase in response to sepsis.