MYOZ2 and heart failure: Notably, miR-582-5p expression was downregulated in Calcineurin-transgenic (Molkentin et al., 1998) and CS1-KO mice (Frey et al., 2004b; Rangrez et al., 2017; Schoensiegel et al., 2007), but upregulated in MLP-KO (Arber et al., 1997) mice, all well-established genetic models of cardiomyopathy and heart failure (Figure 1A).