MYOZ2 and dilated cardiomyopathy: To this end, we employed two well-established in vivo experimental systems: pressure overload via transverse aortic constriction (TAC) (Bosch et al., 2021; Rockman et al., 1991), and the Calsarcin-1-knockout (CS1-KO) mouse model of dilated cardiomyopathy (Frey et al., 2004b; Osio et al., 2007; Rangrez et al., 2017; Schoensiegel et al., 2007).