CKD may also be associated with intrinsic or genetic disorders, including Larsen syndrome, Desbuquois syndrome, Collins-Pope syndrome, Marfan syndrome, Down syndrome, Ehlers-Danlos syndrome, and Golgi-resident 3'-phosphoadenosine-5'-phosphate phosphatase (GPAPP) deficiency [4-6]. The gene discussed is BPNT2; the disease is Desbuquois syndrome.