In thyroid carcinoma, PSMB8 is upregulated and independently prognostic; its elevation correlates with nodal metastasis and extrathyroidal extension yet paradoxically aligns with a favorable prognosis and an inflamed microenvironment, including higher immune infiltration and checkpoint expression, features consistent with an antigen-presenting, therapy-amenable state (56). Here, PSMB8 is linked to thyroid gland carcinoma.