PSMD2 and neoplasm: Moreover, the 19S regulatory subunit PSMD2 is overexpressed in HCC with poor prognosis, high checkpoint expression, and TIDE (Tumor Immune Dysfunction and Exclusion) immune evasion, indicating that proteasome-axis biomarkers are not all equal antigenicity surrogates; some of them are proteins that serve as markers of immunotherapy resistance and proteostasis adaptation (58).