Analysis of metastatic CRC samples mirrored these findings: STAT1-high tumors exhibited more immunogenic microenvironments, characterized by higher tumor and stromal MHC-I/PD-L1 expression and increased TILs, along with transcriptomic signatures of IFNγ, HLA-A/E/G, and cytotoxic effectors (125). This evidence concerns the gene STAT1 and neoplasm.