Hallmark gene sets (Figure 3C) showed enrichment in “Epithelial Mesenchymal Transition (EMT)”, a pivotal process driving metastatic dissemination; “Inflammatory Response”, which nurtures a pro-tumor inflammatory niche; “Myogenesis”, suggesting aberrant muscle-related gene expression that may alter tumor stroma dynamics; “Allograft Rejection”, hinting at immune evasion mechanisms; and “KRAS Signaling Up”, a pathway frequently mutated in CRC to sustain oncogenic signaling. Here, KRAS is linked to neoplasm.