Additionally, research indicated that dioscin, another bioactive metabolite of Polygonati rhizoma, arresting the G2/M phase of tumor cells through the upregulation of p53, Caspase-3, Caspase-9, and Bax, concomitant with the downregulation of Bcl-2 (Luo, 2024). This evidence concerns the gene CASP3 and neoplasm.