The matrine derivative MD-1 engages EGFR on HSC-T6 cells to suppress EGFR/AKT phosphorylation, downregulate cyclin D1, and block persistent HSC activation; in DMN–induced rat fibrosis, MD-1 attenuates disease progression, improves liver function, and preserves hepatocyte integrity (Feng et al., 2016). This evidence concerns the gene LY86 and fibrosis.