STAT3 and Hepatic fibrosis: In the presence of inflammation, interleukin-6 (IL-6) could activate janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling pathway of which has been reported to lead to liver fibrosis (Ilamathi et al., 2016; Ruan et al., 2021; Schmidt-Arras and Rose-John, 2016).