In both in vitro and in vivo liver fibrosis model, it suppresses HSC activation by inhibiting TGF-β1/Smad3 pathway thus reduces α-SMA and collagen I expression as well as targets JAK2/STAT3 pathway to regulate cell proliferation and apoptosis (El-Lakkany et al., 2018; Hu et al., 2018; Tang et al., 2020). Here, SMAD3 is linked to Hepatic fibrosis.