TOP2A and hypertensive disorder: Neuropharmacological Effects: Interacts with cholinergic, adrenergic, and opioid receptors, affecting neurotransmission. Cardiovascular Regulation: Blocks calcium channels and regulates β-adrenergic receptors, reducing hypertension and arrhythmias. Anti-inflammatory: Inhibits Toll-like receptor 4 (TLR4) and NF-κB pathways, reducing inflammatory cytokines. Antibacterial and Antiviral: Targets bacterial DNA gyrase and viral replication enzymes, inhibiting pathogen growth