Furthermore, astrocytes (a type of glial cell) have acetaldehyde dehydrogenase 2 (ALDH2) which leads to the formation of acetate, which contributes to severe intoxication and alcohol dependence (Carmichael et al., 1991; Volkow et al., 2013; Mews et al., 2019; Jin et al., 2021). The gene discussed is ALDH2; the disease is alcohol dependence.